Gilman Reagents (Organocuprates): How They’re Made

Gilman Reagents (Organocuprates): How They’re Made

January 29, 2016

Here’s the summary for today’s post: Organometallics: What About The Rest Of The Periodic Table? In this whole series on organometallics so far has covered exactly TWO metals: lithium and magnesium (with a…

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Grignard Reactions And Synthesis (2)

Grignard Reactions And Synthesis (2)

January 19, 2016

Here’s the summary for today’s post on synthesis incorporating Grignard reagents and oxidants: Synthesis Using Grignard Reagents (Part 2) In the last post we saw how to approach some fairly straightforward…

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Synthesis Using Grignard Reagents (1)

Synthesis Using Grignard Reagents (1)

January 13, 2016

Here’s the bottom line for today’s post on solving synthesis problems involving Grignard reagents. Solving Synthesis Problems Involving Grignard Reagents Now that we’ve covered some of the most impor…

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Protecting Groups In Grignard Reactions

Protecting Groups In Grignard Reactions

December 16, 2015

Now that we’ve gone over the most useful reactions of Grignard reagents – addition to epoxides, aldehydes, ketones, and esters – let’s go back to the topic of how to make Grignard reagents, al…

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Reactions of Grignard Reagents

Reactions of Grignard Reagents

December 10, 2015

Here’s the summary for today’s post: So far in this series we’ve introduced organometallic compounds and said that their carbons tend to be nucleophilic. We’ve learned how to make them from alk…

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Organometallics Are Strong Bases

Organometallics Are Strong Bases

November 13, 2015

Last post we talked about how to make certain organometallics, specifically Grignard and organolithium reagents. One thing we saw is that it’s useful to think of them as “carbanions”, that is, carbon…

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Synthesis of Grignard and Organolithium Reagents

Synthesis of Grignard and Organolithium Reagents

November 9, 2015

In the last post we introduced the concept of organometallic compounds – molecules where carbon is bound to a less electronegative atom such as Li, Mg, Cu, and many other metals. We said that carbon in these mol…

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What’s An Organometallic?

What’s An Organometallic?

October 28, 2015

Quick summary for today – the first in a new series on organometallic compounds: Previously on MOC we’ve discussed how important dipoles are in determining the reactivity of a molecule. Wait: dipoles, yo…

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I Memorized 875 North American Birds During Paternity Leave

I Memorized 875 North American Birds During Paternity Leave

October 20, 2015

What I Learned From A Massive Memorization Project This spring I had a weird obsession with birds. I ended up learning the names of all 875 birds of North America and trained myself to recite them from memory. It was …

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This Is Why Students Use Flashcards

This Is Why Students Use Flashcards

October 2, 2015

A long but interesting letter from a reader who I’ll call “Annie” on how preparing for an exam the “right way” (learning the mechanisms for every reaction) as opposed to the ‘wrong …

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