Organic Chemistry 1

Grignard Reactions And Synthesis (2)

Grignard Reactions And Synthesis (2)January 19, 2016

Here’s the summary for today’s post on synthesis incorporating Grignard reagents and oxidants: Synthesis Using Grignard Reagents (Part 2) In the last post we saw how to approach some fairly straightforward…

Organometallics Are Strong Bases

Organometallics Are Strong BasesNovember 13, 2015

Last post we talked about how to make certain organometallics, specifically Grignard and organolithium reagents. One thing we saw is that it’s useful to think of them as “carbanions”, that is, carbon…

Synthesis of Grignard and Organolithium Reagents

Synthesis of Grignard and Organolithium ReagentsNovember 9, 2015

In the last post we introduced the concept of organometallic compounds – molecules where carbon is bound to a less electronegative atom such as Li, Mg, Cu, and many other metals. We said that carbon in these mol…

What’s An Organometallic?

What’s An Organometallic?October 28, 2015

Quick summary for today – the first in a new series on organometallic compounds: Previously on MOC we’ve discussed how important dipoles are in determining the reactivity of a molecule. Wait: dipoles, yo…

Thiols And Thioethers

Thiols And ThioethersJuly 5, 2015

Here’s a summary of today’s post on thiols: Thiols and Thioethers One of the most powerful insights from learning the periodic table is the fact elements in the same period (column) have similar chemical …

Protecting Groups For Alcohols

Protecting Groups For AlcoholsJune 17, 2015

Summary for today’s post on Protecting Groups: When Alcohols Get In the Way As we’ve seen in previous posts in this series, alcohols are very versatile functional groups that participate in a variety of re…

Intramolecular Reactions of Alcohols and Ethers

Intramolecular Reactions of Alcohols and EthersJune 12, 2015

“Intramolecular Reactions Make Me Crumple Into The Fetal Position Crying For My Mommy” Here’s a topic which doesnt really fit neatly in with what we’ve discussed before but it’s essential to any …

PBr3 and SOCl2

PBr3 and SOCl2March 20, 2015

Lately we’ve been talking a lot about converting alcohols to good leaving groups [halides] [tosylates and mesylates] You might think we’d be done already, but not yet! In today’s post we talk about a…

Tosylates And Mesylates

Tosylates And MesylatesMarch 10, 2015

Today we’re going to talk about a different way of making alcohols into good leaving groups – by turning them into tosylates and mesylates (“organosulfonates”). Here’s a brief summary o…

Making Alkyl Halides From Alcohols

Making Alkyl Halides From AlcoholsFebruary 27, 2015

Making Alkyl Halides From Alcohols In today’s post we show that treating alcohols with HCl, HBr, or HI (which all fall under the catch-all term “HX” where X is a halide) results in the formation of a…