1,4-addition of organocuprates (Gilman reagents) to enones

by James

Description: Organocuprates (aka “Gilman reagents”) will add to alpha beta unsaturated ketones to give 1,4-addition products (aka “Michael addition” products). Acid is added at the end to neutralize the compound.
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{ 2 comments… read them below or add one }

Karhtik Devaraj

In this above reaction why the copper add to 1,4 carbon not to the carbonyl?


Brian Butler

The copper doesn’t add – the alkane attached to the Gilman reagent adds.


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