Conversion of carboxylic acids to carboxylates using base

by James

Description: When treated with base, carboxylic acids form carboxylate salts.
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{ 2 comments… read them below or add one }

KIWOONG YOO

why can’t grignard reagent 1,2-addition to the carboxylic acid? can i happen with acid catalyst making a good L.G?

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James

Because the carboxylic acid would protonate the Grignard reagent, destroying it. Once deprotonated, the carboxylate is a poorer electrophile. Grignard reagents are generally ineffective in adding to them.

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