dasdas

Master Organic Chemistry Reaction Guide

Nucleophilic Aromatic Substitution (SNAr)

Description: Aromatic rings containing electron withdrawing groups and a leaving group can undergo substitution reactions when treated with strong nucleophiles.

This page is available to MOC Members only.
Sign up here for about 30 cents/ day!


Real-Life Example:

Org. Synth. 1934, 14, 66

DOI Link: 10.15227/orgsyn.014.0066

Click to Flip

Comments

Comment section

4 thoughts on “Nucleophilic Aromatic Substitution (SNAr)

  1. for question number #4 quiz ID: 1845, why is the nucleophile attached to the meta position? I thought it could only be possible on ortho and para for SNAr

    1. Hi Stephanie – yes, come to think of it you are correct. I’m going to adjust this, since the resulting negative charge after addition of nucleophile wouldn’t be very stabilized.

      Thanks!!

  2. For the last diagram showing resonance you said “what about attack at the carbon ‘ortho’ to the nitro group” , but you meant to say meta.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.