Oxidative Cleavage of Alkynes with KMnO4
Description: Potassium permanganate (KMnO4) will cleave alkynes to give carboxylic acids.
Notes: The same reaction can be performed with ozone (O3)
Notes: Note where a terminal alkyne is being cleaved (examples 2 and 4) one of the products is carbon dioxide.
Mechanism: For the purposes of Org 1 / Org 2 the mechanism of this reaction is not considered “important”. However the first step is almost certainly the cycloaddition of MnO4 to the triple bond, followed by oxidative cleavage.