Protection of alcohols as silyl ethers

Description: Alcohols can be converted into silyl ethers with trimethylsilyl chloride (TMSCl) or similar silyl groups. This is a useful procedure for the protection of alcohols.
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- 1,4-addition of enolates to enones (“The Michael Reaction”)
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- Oxidative cleavage of alkenes to ketones/carboxylic acids using KMnO4
- Oxidative Cleavage of Alkynes with KMnO4
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- Oxymercuration of Alkenes to form Ethers using Hg(OAc)2
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- Partial reduction of alkynes to trans alkenes using sodium and ammonia
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- Reduction of carboxylic acids to primary alcohols using LiAlH4
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- SN2 reaction of amines with alkyl chlorides to give ammonium salts
- SN2 reaction of carboxylate ions with alkyl halides to give esters
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- SN2 reaction of organocuprates (Gilman reagents) with alkyl halides to give alkanes
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- Substitution (SN1) with hydride shift
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- The Robinson Annulation
- Transesterification promoted by alkoxides
- Wittig Reaction – conversion of ketones/aldehydes to alkenes
- Wolff Kishner Reaction – conversion of ketones/aldehydes to alkanes
- Wolff Rearrangement
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