Nucleophilic Acyl Substitution (With Negatively Charged Nucleophiles) Yes, there are a lot of reactions of carboxylic acid derivatives to learn! In this article we’ll explore
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Synthesis, Nomenclature, and Properties Of The Amide Functional Group In this post, we’ll try to provide a broad overview of amides. We’ll provide a brief
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Peptide bonds: Forming peptides from amino acids with the use of protecting groups Today we’ll go deeper on how to synthesize the most important amides
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Lithium Aluminum Hydride (LAH, LiAlH4) For the Reduction of Carboxylic Acid Derivatives Lithium aluminum hydride (LiAlH4) is a strong reducing agent similar to, but stronger
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Sodium Amide (Sodamide, NaNH2), A Strong Base For The Deprotonation Of Terminal Alkynes (Among Other Uses) In a blatant plug for the Reagent Guide, each Friday
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How To Recognize Primary, Secondary, Tertiary (and sometimes Quaternary) Hydrocarbons, Carbocations, Alkyl Halides, Alcohols, Amines, and Amides. Primary (1°), secondary (2°), tertiary (3°) and quaternary
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Amide Hydrolysis – Conversion of Amides To Carboxylic Acids In this post we discuss examples and mechanism of acidic hydrolysis of amides, as well as
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