Basicity of Amines And pKaH
Quantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read moreQuantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read more5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreA Puzzle In The Basicity Of Some Disubstituted Aromatic Amines We’ve seen that several key factors influence the basicity of amines – charge, resonance, inductive
Read moreNucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a lot of coverage in many organic chemistry courses, but if we’re going to cover
Read moreWhy Alkylation Of Amines (aka “The Williamson Ether Synthesis, But For Amines” ) Usually Doesn’t Pan Out Making a more-substituted amine from a less-substituted amine
Read moreMaking Substituted Amines Through Reductive Amination Direct alkylation of amines with alkyl halides is a difficult reaction to control. One alternative that works extremely well
Read moreThe Gabriel Synthesis For Making Primary Amines We’ve seen previously that it’s hard to *usefully* build amines through the SN2 reaction, because once amines start
Read moreHere’s the thing about the coverage of “amines” in Org 2: there’s no narrative. Unlike most chapters, it doesn’t start with a set of concepts
Read morePeptide bonds: Forming peptides from amino acids with the use of protecting groups Today we’ll go deeper on how to synthesize the most important amides
Read moreDiazonium Salts From Amines, And Reactions Of Diazonium Salts Today let’s talk about a set of reactions of aromatic amines, that variously are catalogued under
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