Nucleophilic Acyl Substitution (With Negatively Charged Nucleophiles) Yes, there are a lot of reactions of carboxylic acid derivatives to learn! In this article we’ll explore
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The Second-Most Important Mechanism In Carbonyl Chemistry – Carbonyl Elimination The reverse of nucleophilic addition to the C=O bond (giving a tetrahedral intermediate) is elimination
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Introduction to Elimination Reactions As you’ve probably noticed by now, organic chemistry is a lot different from physics. When we’re looking to predict what reaction
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Proton Transfer All acid-base reactions are technically proton transfers, where a bond to H+ breaks, and a bond to H+ forms. However, the term “proton
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All About Tosylates and Mesylates By themselves, alcohols are poor leaving groups since the hydroxide ion (HO-) is a strong base The OH group can
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PBr3 and SOCl2: Reagents For Converting Alcohols To Good Leaving Groups Alcohols can be converted into alkyl halides with phosphorus tribromide (PBr3) or thionyl chloride
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The Important Role of The Counter-Ion In Determining E1 vs SN1 E1 will generally be favored over SN1 when heat is applied Secondly, in E1
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Following up on the 4 most important patters of reactions in Org 1, and introduction to acid-base reactions, here’s the second major pattern. It’s called
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The SN2 Reaction Mechanism Having gone through the two different types of substitution reactions, and talked about nucleophiles and electrophiles, we’re finally in a position
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The SN1 Reaction Mechanism There are two important classes of nucleophilic substitution mechanisms – the SN1 and SN2 mechanisms. The SN1 mechanism is distinct from
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