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leaving groups

Proton Transfer

Proton Transfer All acid-base reactions are technically proton transfers, where a bond to H+ breaks, and a bond to H+ forms. However, the term “proton

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Tosylates And Mesylates

All About Tosylates and Mesylates By themselves, alcohols are poor leaving groups since the hydroxide ion (HO-) is a strong base The OH group can

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PBr3 and SOCl2

PBr3 and SOCl2: Reagents For Converting Alcohols To Good Leaving Groups Alcohols can be converted into alkyl halides with phosphorus tribromide (PBr3) or thionyl chloride

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The SN2 Mechanism

The SN2 Reaction Mechanism Having gone through the two different types of substitution reactions, and talked about nucleophiles and electrophiles, we’re finally in a position

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The SN1 Mechanism

The SN1 Reaction Mechanism There are two important classes of nucleophilic substitution mechanisms – the SN1 and SN2 mechanisms. The SN1 mechanism is distinct from

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