Acetylides from Alkynes, And Substitution Reactions of Acetylides
Alkylation of acetylides Terminal alkynes have unusually acidic C–H bonds (pKa 25). Treatment with a strong base such as sodium amide (NaNH2) gives an acetylide,
Read moreAlkylation of acetylides Terminal alkynes have unusually acidic C–H bonds (pKa 25). Treatment with a strong base such as sodium amide (NaNH2) gives an acetylide,
Read moreIntroduction to Rearrangement Reactions Reactions that involve a carbocation intermediate may be accompanied by rearrangements where a pair of electrons from a C-H or C-C bond
Read moreIdentifying Carbons Where Substitution and Elimination Reactions Can Take Place Substitution and elimination reactions need a leaving group in order for them to occur. Look
Read moreThe Role of The Substrate In Substitution & Elimination Reaction: SN2 vs E1/SN1 Deciding whether a reaction is SN1/SN2/E1/E2 first of all requires understanding the
Read moreIntroduction to Elimination Reactions As you’ve probably noticed by now, organic chemistry is a lot different from physics. When we’re looking to predict what reaction
Read moreAll About Tosylates and Mesylates By themselves, alcohols are poor leaving groups since the hydroxide ion (HO-) is a strong base The OH group can
Read morePBr3 and SOCl2: Reagents For Converting Alcohols To Good Leaving Groups Alcohols can be converted into alkyl halides with phosphorus tribromide (PBr3) or thionyl chloride
Read moreSN1 / SN2 / E1 / E2 The Nucleophile / Base This article assumes you understand the mechanisms of the SN1/SN2/E1 and E2 reactions. For
Read moreFree Radical Reactions – Chlorination of Methane Alkanes are pretty boring, chemically speaking. They don’t tend to undergo many reactions. However, when they are treated
Read moreSN1 vs E1, and SN2 vs. E2: The Role Of Heat This article assumes you understand the mechanisms of the SN1/SN2/E1 and E2 reactions. For
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