Acetylides from Alkynes, And Substitution Reactions of Acetylides
Alkylation of acetylides Terminal alkynes have unusually acidic C–H bonds (pKa 25). Treatment with a strong base such as sodium amide (NaNH2) gives an acetylide,
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Reaction Maps Now Available
The Reaction Map PDF from Master Organic Chemistry (MOC) is a 15-page summary of the key reactions in introductory organic chemistry.
Read moreAromatic Synthesis (1) – “Order Of Operations”
Planning An Aromatic Synthesis: Putting Reactions In The Right Order When planning a synthesis of simple aromatic compounds, it’s not enough to pick the right
Read moreSynthesis of Benzene Derivatives (2) – Polarity Reversal
Synthesis of Benzene Derivatives: Converting ortho-,para- directors into meta- directors and vice versa. In planning the synthesis of simple benzene derivatives and other aromatic compounds,
Read moreSynthesis (7): Reaction Map of Benzene and Related Aromatic Compounds
Reactions of Benzene and Aromatic Compounds: A Reaction Map (PDF) Let’s map out all of the reactions we’ve learned in this section on aromatic rings
Read moreSynthesis Problems Involving Grignard Reagents
Grignard Practice Problems: Synthesis Exercises Involving Grignard Reagents Grignard reagents add once to aldehydes to give secondary alcohols and also add once to ketones to give tertiary
Read moreGrignard Reactions And Synthesis (2)
More Grignard Practice Problems, This Time Incorporating Oxidation Here’s the summary for today’s post on synthesis incorporating Grignard reagents and oxidants. Converting an aldehyde into
Read moreThe 8 Types of Arrows In Organic Chemistry, Explained
To my knowledge there are 8 different types of arrows you meet in organic chemistry. Here’s a little guide to them. 1. The forward arrow,
Read moreAlcohols To Ethers via Acid Catalysis
How To Make Ethers With Alcohols And Acid Symmetrical ethers can be made from the acid-catalyzed dehydration of primary alcohols. A classic example is the
Read morePartial Reduction of Alkynes With Lindlar’s Catalyst
Partial Reduction of Alkynes to cis Alkenes with the Lindlar Catalyst Alkynes are generally more reactive towards catalytic hydrogenation (e.g. Pd-C, H2) than alkenes While
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