Ace Your Next Organic Chemistry

With these Downloadable PDF Study Guides

Our Study Guides

The Robinson Annulation

The Robinson Annulation The Robinson Annulation is the name for a process that combines two key reactions you’ve learned previously into one longer sequence. The

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Summary Sheet: Additions to Carbonyls

I put together this summary sheet for the reaction of nucleophiles with carbonyls (click for larger image, see link to downloadable PDF below). It summarizes the two key concepts that are important to understand for these reactions: the effect of electronic and steric factors on nucleophilic addition.

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Some Perspective

For all of those thinking about med school: organic chemistry is not hard. . Complex? Yes. Challenging? Of course. A lot of facts and concepts to memorize

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A simple trick: The (R)-(S) Toggle

Instead of redrawing the whole molecule, just leave the hydrogen (or other 4th ranked substituent) in front and figure out whether the substituents ranked 1,2, and 3 go clockwise or counterclockwise. Then toggle (i.e. reverse direction CW to CCW or vice versa) to account for the fact that the 4th ranked substituent is in the front, and assign (R) or (S) based on that. You end up with the same answer without having to redraw anything.

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