Synthesis

Synthesis (7): Reaction Map of Benzene and Related Aromatic Compounds

Synthesis (7): Reaction Map of Benzene and Related Aromatic Compounds

November 19, 2018

Let’s map out all of the reactions we’ve learned in this section on aromatic rings + substituents. Also included is a few reactions we actually haven’t covered yet – such as diazonium salt form…

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Aromatic Synthesis (1) – “Order Of Operations”

Aromatic Synthesis (1) – “Order Of Operations”

October 15, 2018

Up to now, we’ve covered electrophilic aromatic substitution [6 key reactions] [mechanism] [ortho-para-meta] and then the reactions of aromatic substituents [bromination & oxidation] [carbonyl reduction] [n…

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Protecting Groups for Amines – Carbamates

Protecting Groups for Amines – Carbamates

June 7, 2018

An Introduction To Simple Peptide Synthesis In a recent post [Amides: Synthesis, Properties, and Nomenclature] we went through 3 common ways of making amides: Adding amines to acyl halides / anhydrides Partial hydroly…

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Grignard Reactions And Synthesis (2)

Grignard Reactions And Synthesis (2)

January 19, 2016

Here’s the summary for today’s post on synthesis incorporating Grignard reagents and oxidants: Synthesis Using Grignard Reagents (Part 2) In the last post we saw how to approach some fairly straightforward…

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Synthesis Using Grignard Reagents (1)

Synthesis Using Grignard Reagents (1)

January 13, 2016

Here’s the bottom line for today’s post on solving synthesis problems involving Grignard reagents. Solving Synthesis Problems Involving Grignard Reagents Now that we’ve covered some of the most impor…

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Synthesis (6) – Reactions of Alcohols

Synthesis (6) – Reactions of Alcohols

July 27, 2015

The Alcohol Reaction Map Having now finished (at long last) covering the key reactions of alcohols, let’s stop to put everything in perspective. Over the past 18 posts, we covered reactions such as: Ether format…

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Williamson Ether Synthesis: Planning

Williamson Ether Synthesis: Planning

October 30, 2014

In the last post we introduced the Williamson ether synthesis,  one of the most straightforward ways we know of to make an ether. If you’ve been in the trenches long enough, you would have also noticed that it…

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How Concepts Build Up In Org 2

How Concepts Build Up In Org 2

September 9, 2014

OK. Having looked at the Org 1 Concept Map, let’s ask the next logical question: what does a typical Org 2 course look like? One general observation: the way functional groups are covered in your typical two-semeste…

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Synthesis (5) – Reactions of Alkynes

Synthesis (5) – Reactions of Alkynes

January 29, 2014

Today, we’re going to add the reactions of alkynes to our reaction map, which will bring to a close all the major reactions we’ve discussed so far in a typical first semester course. Like alkenes, the main…

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Synthesis (4) – Reactions of Alkenes

Synthesis (4) – Reactions of Alkenes

January 21, 2014

In the last post on alkenes we covered the reactions of alkyl halides and it made out tiny little reaction map explode into a cascade.  Here we’re really going to blow up our reaction map, because we’re g…

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