Acetylides from Alkynes, And Substitution Reactions of Acetylides
Alkylation of acetylides Terminal alkynes have unusually acidic C–H bonds (pKa 25). Treatment with a strong base such as sodium amide (NaNH2) gives an acetylide,
Read moreAlkylation of acetylides Terminal alkynes have unusually acidic C–H bonds (pKa 25). Treatment with a strong base such as sodium amide (NaNH2) gives an acetylide,
Read moreNucleophilic Acyl Substitution (With Negatively Charged Nucleophiles) Yes, there are a lot of reactions of carboxylic acid derivatives to learn! In this article we’ll explore
Read moreAcid-Base Reactions Of Alcohols Alcohols are mild acids. Typical aliphatic (i.e. “alkyl”) alcohols such as ethanol, isopropanol, and t-butanol have a pKa of about 16-18, making
Read moreCarboxylic acids… are acids. I know that seems obvious. But it’s a near certainty that students taking Org 2 for the first time will forget
Read moreUnderstanding The 7 Key Factors That Stabilize Negative Charge (And Ultimately, Basicity) Like I wrote about in a previous post, it’s good – but not
Read moreAn Introduction to Acid Base Reactions In Organic Chemistry Now that we’ve described how to figure out where the electrons are in a molecule, the
Read moreAcidity Trends In Organic Molecules Here, we’ll review the key trends that affect acidity, which all have the common effect of stabilizing negative charge (or more broadly,
Read moreFive Key Factors That Affect Acidity Today we’ll talk about what’s behind the trends in acidity for different molecules and discuss the most important factors
Read moreThe Acidity Constant Ka (And Its Negative Logarithm pKa ) Is An Extremely Useful Measure Of Acidity So last time we went through all the
Read moreToday we’ll talk about an incredibly important skill that might take some time to grasp but pays tremendous dividends. We’ll go through the exact details of how to use a pKa table. Understanding the proper use of a pKa table will give you the ability to recognize which acid-base reactions will happen and which will not. This will come up a lot as you progress through Org 1 and Org 2. It might be helpful to go back and review some of the factors that affect acidity that were talked about earlier.
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