Master Organic Chemistry

The Hofmann Elimination

October 18, 2017 By James Ashenhurst 3 Comments

The Hofmann Elimination is an elimination reaction of alkylammonium salts that forms C-C double bonds [pi bonds]. [note] It proceeds through a concerted E2 mechanism. In contrast with most elimination reactions that yield alkenes, which follow the Zaitsev (Saytzeff) rule, the Hofmann elimination … [Read more...]

Filed Under: Amines, Organic Chemistry 2 Tagged With: ammonium salt, e2, elimination, gauche, hofmann degradation, hofmann elimination, pkah, steric hindrance

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