Enolates – Formation, Stability, and Simple Reactions
All about enolates Enolates can be formed through removing the proton on carbons adjacent to a carbonyl (i.e. the “alpha-carbon“). The resulting anions are much
Read moreAll about enolates Enolates can be formed through removing the proton on carbons adjacent to a carbonyl (i.e. the “alpha-carbon“). The resulting anions are much
Read moreKinetic versus Thermodynamic Enolates of Ketones Enolates have a lot in common with alkenes. They are flat and have a C-C pi bond. Zaitsev’s rule
Read moreThe Michael Addition Reaction (and Conjugate Addition) The Michael reaction (sometimes “Michael Addition”) is the addition of an enolate to an electrophilic alkene, such as
Read moreLithium Diisopropyl Amide (LDA), A Strong, Sterically Hindered Base In a blatant plug for the Reagent Guide, each Friday I profile a different reagent that is
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