In this post we'll discuss nucleophilic aromatic substitution, but with a new twist; a nucleophilic aromatic substitution that passes through a strange-looking intermediate called an aryne (a generic term for a family of molecules that includes benzyne). Previously [see: Nucleophilic Aromatic … [Read more...]
Alkynes Via Elimination Reactions
We've gone through elimination reactions before - treatment of alkyl halides with base gives alkenes. Some time ago we discussed elimination reactions here. Elimination reactions follow the general pattern below, where two adjacent bonds to carbon are broken - usually C-H and C-X, where X is a … [Read more...]
Reagent Friday: Sodium Amide (NaNH2)
In a blatant plug for the Reagent Guide, each Friday I profile a different reagent that is commonly encountered in Org 1/ Org 2. Version 1.2 just got released this week, with a host of corrections and a new page index. Note: there should also be another exciting announcement about the Reagent … [Read more...]