Basicity of Amines And pKaH
Quantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
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5 Key Basicity Trends of Amines
5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreAlcohols – Acidity and Basicity
Acid-Base Reactions Of Alcohols Alcohols are mild acids. Typical aliphatic (i.e. “alkyl”) alcohols such as ethanol, isopropanol, and t-butanol have a pKa of about 16-18, making
Read moreEpoxide Ring Opening With Base
Ring-opening of epoxides with basic nucleophiles Epoxides are cyclic ethers with considerable ring strain (about 13 kcal/mol) Epoxides undergo reaction with nucleophiles under basic conditions
Read moreTosylates And Mesylates
All About Tosylates and Mesylates By themselves, alcohols are poor leaving groups since the hydroxide ion (HO-) is a strong base The OH group can
Read moreThe Stronger The Acid, The Weaker The Conjugate Base
Basicity In Organic Chemistry: Some Basicity Trends Today we’ll look at a simple periodic basicity trend across the periodic table and extrapolate from it some
Read moreWalkthrough of Acid-Base Reactions (3) – Acidity Trends
Acidity Trends In Organic Molecules Here, we’ll review the key trends that affect acidity, which all have the common effect of stabilizing negative charge (or more broadly,
Read moreAcid-Base Reactions: Introducing Ka and pKa
The Acidity Constant Ka (And Its Negative Logarithm pKa ) Is An Extremely Useful Measure Of Acidity So last time we went through all the
Read moreA Handy Rule of Thumb for Acid-Base Reactions
Reversible And Irreversible Acid-Base Reactions Last time we learned about pKa and how it’s the closest thing we have to a universal measurement of the
Read moreAcid Base Reactions Are Fast
Acid-Base Reactions Are Generally Faster Than Substitution Or Addition Reactions Here is a very common dilemma in organic chemistry as you move through the latter parts
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