Today we'll go deeper on how to synthesize the most important amides of all - peptides - with an important contribution from protecting group chemistry. Peptide Bond Formation A "peptide bond" is an amide linkage (see Amides: Properties. Synthesis, and Nomenclature) that connects two amino acids, … [Read more...]
Protecting Groups In Grignard Reactions
Now that we've gone over the most useful reactions of Grignard reagents - addition to epoxides, aldehydes, ketones, and esters - let's go back to the topic of how to make Grignard reagents, albeit with a twist. Here's the summary for today's post: Introducing Yet Another Way To Royally Screw … [Read more...]
Protecting Groups For Alcohols
Summary for today's post on Protecting Groups: When Alcohols Get In the Way As we've seen in previous posts in this series, alcohols are very versatile functional groups that participate in a variety of reactions. They can be deprotonated with base (making them good nucleophiles in … [Read more...]