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Introduction to Peptide Synthesis

February 15, 2019 By James Ashenhurst Leave a Comment

Today we'll go deeper on how to synthesize the most important amides of all - peptides - with an important contribution from protecting group chemistry. Peptide Bonds A "peptide bond" is an amide linkage (see Amides: Properties. Synthesis, and Nomenclature)  that connects two amino acids, as in … [Read more...]

Filed Under: Amines Tagged With: amides, amines, boc, dcc, fmoc, peptides, protecting groups

Protecting Groups In Grignard Reactions

December 16, 2015 By James Ashenhurst 2 Comments

Now that we've gone over the most useful reactions of Grignard reagents - addition to epoxides, aldehydes, ketones, and esters - let's go back to the topic of how to make Grignard reagents, albeit with a twist. Here's the summary for today's post: Introducing Yet Another Way To Royally Screw … [Read more...]

Filed Under: Organic Chemistry 2 Tagged With: acetals, grignard reagents, organometallics, protecting groups

Protecting Groups For Alcohols

June 17, 2015 By James Ashenhurst 8 Comments

Summary for today's post on Protecting Groups: When Alcohols Get In the Way As we've seen in previous posts in this series, alcohols are very versatile functional groups that participate in a variety of reactions. They can be deprotonated with base (making them good nucleophiles in … [Read more...]

Filed Under: Alcohols, Organic Chemistry 1 Tagged With: alcohols, dhp, protecting groups, tbs, tbscl, thp, tmscl, trimethylsilyl

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