Aldol addition reaction of aldehydes and ketones

by James

Description: The Aldol reaction is the addition of an enolate ion with an aldehyde or ketone.
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{ 4 comments… read them below or add one }

James April 18, 2012 at 6:10 pm

Hi,
I am slightly confused about the first two examples as it seems that the enolate formed from the least substituted carbonyl compound without the use of LDA?
Many thanks for an excellent website.

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james April 18, 2012 at 11:03 pm

Aha! Look more closely… what enolates are possible here?

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Petr Menzel May 26, 2014 at 3:11 am

Hi, is there possibility to use Na2CO3 like a base? What would be different? Thx, P.

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James May 26, 2014 at 3:40 pm

Sure, one could use Na2CO3 as a base – it’s probably reacting with water present in solution to give trace amounts of HO- , which is doing the deprotonation. Na2CO3 isn’t the greatest base in the world however.

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