Sulfonylation of Arenes to give sulfonic acids

by James

Description: Treatment of an aromatic molecule such as benzene with sulfur trioxide and a strong acid leads to formation of sulfonic acids.
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{ 5 comments… read them below or add one }

T.R.Prajapati April 29, 2012 at 9:56 am

i want to prepare sulfonic acid at small scale give us details.


james April 29, 2012 at 1:00 pm

You should hire a consultant.


Polina Porotsky February 12, 2015 at 4:52 pm

Does sulfonation activate the ring for future electrophilic aromatic substitutions?


James February 12, 2015 at 4:56 pm

No, SO3H is an electron withdrawing group so it actually deactivates the ring. Hope this helps! James


Polina Porotsky February 13, 2015 at 6:09 pm

Wonderful. Thank you. Electron withdrawing due to the electronegative oxygens, and the fact that the Pi orbitals are not the same size? Would it be useful as an instigator for addition-elimination nucleophilic aromatic substitution? (the same way that NO2 is?)


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