Reaction of epoxides with nucleophiles under basic conditions

by James

Description: When epoxides are treated with negatively charged nucleophiles, they will add to the least substituted position of the epoxide in an SN2 reaction.
Content available for Reactionguide members only. Not a member? Get access for about 30 cents / day!

{ 3 comments… read them below or add one }

Anjala Wijayanthi August 11, 2012 at 3:48 am

Thanks a lot . I was wondering how this reaction takes place.


Rajarshi Banerjee October 30, 2012 at 5:25 am

In the second stage of the mechanism its should be H-OH2


Alexander Peltekoff January 29, 2014 at 9:05 pm

Think you could add a page on the opening of epoxides with a Nu to form a Polymer? My text doesn’t show the full mechanism and I would find it really helpful.


Leave a Comment