SN2 reaction of organocuprates (Gilman reagents) with alkyl halides to give alkanes

by James

Description: Alkyl halides (or tosylates) will react with organocuprates (Gilman reagents) to form alkanes in an SN2 reaction
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{ 3 comments… read them below or add one }

Petr Menzel May 22, 2014 at 12:52 pm

Hi, please for explaining how is created bond C1 and C2 in Mechanism? C1 is (+) and Cu is (-) —> C2 is (+) I suppose. Thx. P.

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James May 22, 2014 at 2:55 pm

That is correct. C-2 attached to Cu is nucleophilic (partially negative) and C1 attached to Br is electrophilic (partially positive).

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Petr Menzel May 22, 2014 at 3:23 pm

Oh, my mistake. Electronegativity (Cu) = 1,9 < Electronegativity (C) = 2,5. :-) Thx

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