Master Organic Chemistry Reaction Guide

1,4-addition of organocuprates (Gilman reagents) to enones

Description: Organocuprates (aka “Gilman reagents”) will add to alpha beta unsaturated ketones to give 1,4-addition products (aka “Michael addition” products). Acid is added at the end to neutralize the compound.
Content available for Reactionguide members only. Not a member? Get access for about 30 cents / day!


Comment section

2 thoughts on “1,4-addition of organocuprates (Gilman reagents) to enones

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.