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Master Organic Chemistry Reaction Guide

Addition Of Alcohols To Alkenes With Acid

Description: Alkenes treated with acid in the presence of an alcohol (usually as solvent) form ethers.

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Real-Life Example:

Org. Synth. 1940, 20, 81

DOI Link: 10.15227/orgsyn.020.0081

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4 thoughts on “Addition Of Alcohols To Alkenes With Acid

  1. During the final deprotonation step, does one have to consider the pKa’s of both the R-OH and the H+ in order to properly write out the mechanism?

    1. I don’t think so. There’s often multiple species in solution that are competent to act as a base on a strong acid like protonated alcohol (pKa -3). I drew HSO4- here to complete the catalytic cycle but honestly it could be a number of different species. That’s why people often just like to write, “B” for generic base.

    1. Sure. First step is that the alkene reacts with H+ to form C-H on the less substituted carbon, leaving behind a tertiary carbocation. This tertiary carbocation is 5 bonds away from the oxygen. 5 membered rings are nice and easy to form. So the oxygen lone pair attacks the carbocation generating a new 5- membered ring which is then deprotonated.

      Intramolecular reactions are great exam questions.

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