Master Organic Chemistry Reaction Guide

Alkylation of enamines with alkyl halides

Description: Enamines are nucleophiles, and will react with alkyl halides to give alkylation products. Subsequent treatment with aqueous acid will give ketones.

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Real-Life Example
Org. Synth. 1961, 41, 76
DOI Link: 10.15227/orgsyn.041.0076

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4 thoughts on “Alkylation of enamines with alkyl halides

  1. Just found this to be extremely concise, yet simple. Very thorough and very appreciative. THANK YOU I am doing medicinal and synthetic organic chem, amongst some other units, so such a thorough site like this will be advantageous.
    Best regards to all.

    B

  2. tes: Acid can assist the reaction, making it faster in two ways. First, it makes the carbonyl more reactive for step 2, and it also allows for

    ??where is the carbonyl?

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