Master Organic Chemistry Reaction Guide

Alkylation of enamines with alkyl halides

Description: Enamines are nucleophiles, and will react with alkyl halides to give alkylation products. Subsequent treatment with aqueous acid will give ketones.

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Real-Life Example
Org. Synth. 1961, 41, 76
DOI Link: 10.15227/orgsyn.041.0076

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Comment section

4 thoughts on “Alkylation of enamines with alkyl halides

  1. tes: Acid can assist the reaction, making it faster in two ways. First, it makes the carbonyl more reactive for step 2, and it also allows for

    ??where is the carbonyl?

  2. Just found this to be extremely concise, yet simple. Very thorough and very appreciative. THANK YOU I am doing medicinal and synthetic organic chem, amongst some other units, so such a thorough site like this will be advantageous.
    Best regards to all.


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