Conversion of carboxylic acids to carboxylates using base
Description: When treated with base, carboxylic acids form carboxylate salts.
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Description: When treated with base, carboxylic acids form carboxylate salts.
This page is available to MOC Members only.
Sign up here for about 30 cents/ day!
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why can’t grignard reagent 1,2-addition to the carboxylic acid? can i happen with acid catalyst making a good L.G?
Because the carboxylic acid would protonate the Grignard reagent, destroying it. Once deprotonated, the carboxylate is a poorer electrophile. Grignard reagents are generally ineffective in adding to them.