Master Organic Chemistry Reaction Guide

Formation of Acetals from Aldehydes and Ketones

Description: Ketones (or aldehydes) can be converted into acetals when treated with alcohols and acid. The byproduct is water. 

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Real-Life Examples:

Org. Synth. 1926, 6, 64

DOI Link: 10.15227/orgsyn.006.0064

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Org. Synth. 1962, 42, 1

DOI Link: 10.15227/orgsyn.042.0001

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Comment section

3 thoughts on “Formation of Acetals from Aldehydes and Ketones

  1. Hi James!
    Wow, sincere thanks for the video.
    Just to clarify… You add a base to the reaction only when you need to deprotonate a H, like you did in Step 5. Otherwise, only the nucleophile will participate in addition reactions? Since protonating a ketone will make it more electrophilic, the strength of the nucleophile will not matter?

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