Master Organic Chemistry Reaction Guide

Formation of alkynes through double elimination of vicinal dibromides

Description: Sodium amide will convert 1,2-dihalides (“vicinal dihalides”) into alkynes through two consecutive elimination reactions.
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6 thoughts on “Formation of alkynes through double elimination of vicinal dibromides

  1. My course taught us that we need three molar equivalents of NaNH2 for this reaction, as it prevents the formation of the alkynyl salt.

    1. True, for terminal alkynes. Once the alkyne is formed, it can then be deprotonated by NaNH2 in solution. For practical purposes, three equivalents for the formation of terminal alkynes is best.

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