Formation of amides from acid chlorides and amines

by James

Description: Addition of primary or secondary amines (or ammonia) to acid chlorides results in amides.
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How acid chloride of amino acid synthezed.



For an amino acid like leucine or alanine with non-reactive sidechains, I think you’d need to di-protect the amine as a phthalimide or similar reagent, and then convert it into an acid chloride with SOCl2 or oxalyl chloride. you have to be careful, however – racemization is very facile.


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