Master Organic Chemistry Reaction Guide

Formation of Amides Using DCC

Description: Treatment of carboxylic acids with amines in the presence of the dehydrating agent N,N’-dicyclohexylcarbodiimide (DCC) leads to the formation of amides. This is particularly useful for peptide synthesis.
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3 thoughts on “Formation of Amides Using DCC

  1. DCC also used as dehydrating agent during reactions between alcohols (R’-OH) and carboxylic acids (R-COOH) to form corresponsding esters (R-COOR’).
    However, precaution should be taken during its use because it is a very potent allergen.

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