Master Organic Chemistry Reaction Guide

Formation of Grignard Reagents from Alkyl Halides

Description: Treatment of alkyl halides with magnesium metal leads to formation of a Grignard reagent.

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Real-Life Examples

DOI Link: 10.15227/orgsyn.006.0054

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Org. Synth. 1930, 10, 4

DOI Link: 10.15227/orgsyn.010.0004

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Org. Synth. 1931, 11, 66

DOI Link: 10.15227/orgsyn.011.0066

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Org. Synth. 1932, 12, 48

DOI Link: 10.15227/orgsyn.012.0048

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Org. Synth. 1931, 11, 80

DOI Link: 10.15227/orgsyn.011.0080

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Org. Synth. 1931, 11, 84

DOI Link: 10.15227/orgsyn.011.0084

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Org. Synth. 1947, 27, 65

DOI Link: 10.15227/orgsyn.027.0065

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Comments

Comment section

3 thoughts on “Formation of Grignard Reagents from Alkyl Halides

  1. Would I be correct in stating that the Grignard reagent is so basic, with such a high pKa (approx. 50) that it is able to de-protonate any hydrogen with a lower pKa? Additionally, that in a synthesis it will de-protonate the most acidic hydrogen?

  2. I don’t think I can view the image properly. The arrow pushing looks incorrect. But that’s okay. My book can finish this up, thank you.

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