Master Organic Chemistry Reaction Guide

Hofmann elimination of alkylammonium salts to give alkenes

Description: Tetra-alkyl ammonium salts undergo elimination to form the least substituted alkene. This is called the Hofman elimination.
Content available for Reactionguide members only. Not a member? Get access for about 30 cents / day!


Comment section

6 thoughts on “Hofmann elimination of alkylammonium salts to give alkenes

  1. I appreciate your well presented information. I just wanted to ask whether you meant, under bonds broken, C1-H and not C2-H. That is in the first (i.e, general) equation. Later on, under mechanism, the information looks correct.
    Thank you.

  2. Just curious. What would happen if we tried reacting Tetramethyl Ammonium with a mild base (like AgOH). Since there is no beta Hydrogen to abstract, Hofmann elimination isn’t feasible so what would be the products?

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.