Master Organic Chemistry Reaction Guide

Hydrolysis of acetals to give aldehydes and ketones

Description: Addition of aqueous acid to acetals will transform them back into ketones (or aldehydes). This is often referred to as “deprotection” of ketones (or aldehydes).

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Real-Life Example:

Org. Synth. 1931, 11, 50
DOI Link: 10.15227/orgsyn.011.0050

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Comment section

5 thoughts on “Hydrolysis of acetals to give aldehydes and ketones

  1. Can you explain the last bullet in the opening notes? Isn’t this deprotection and not protection?

  2. Hello – I am a bit confused about the introductory “notes” section. You state that the alcohol is used in great excess over water, but wouldn’t that lead to the formation of the acetal? I would imagine that having water in excess would drive the forward reaction instead.

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