Master Organic Chemistry Reaction Guide

Hydrolysis of acetals to give aldehydes and ketones

Description: Addition of aqueous acid to acetals will transform them back into ketones (or aldehydes). This is often referred to as “deprotection” of ketones (or aldehydes).
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5 thoughts on “Hydrolysis of acetals to give aldehydes and ketones

  1. Hello – I am a bit confused about the introductory “notes” section. You state that the alcohol is used in great excess over water, but wouldn’t that lead to the formation of the acetal? I would imagine that having water in excess would drive the forward reaction instead.

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