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Master Organic Chemistry Reaction Guide

Nucleophilic Aromatic Substitution (SNAr)

Description: Aromatic rings containing electron withdrawing groups and a leaving group can undergo substitution reactions when treated with strong nucleophiles.

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Real-Life Example:

Org. Synth. 1934, 14, 66

DOI Link: 10.15227/orgsyn.014.0066

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2 thoughts on “Nucleophilic Aromatic Substitution (SNAr)

  1. For the last diagram showing resonance you said “what about attack at the carbon ‘ortho’ to the nitro group” , but you meant to say meta.

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