Master Organic Chemistry Reaction Guide

Nucleophilic Aromatic Substitution (SNAr)

Description: Aromatic rings containing electron withdrawing groups and a leaving group can undergo substitution reactions when treated with strong nucleophiles.

This page is available to MOC Members only.
Sign up here for about 30 cents/ day!

Real-Life Example:

Org. Synth. 1934, 14, 66

DOI Link: 10.15227/orgsyn.014.0066

Click to Flip


Comment section

2 thoughts on “Nucleophilic Aromatic Substitution (SNAr)

  1. For the last diagram showing resonance you said “what about attack at the carbon ‘ortho’ to the nitro group” , but you meant to say meta.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.