Master Organic Chemistry Reaction Guide

Protection of alcohols as silyl ethers

Description: Alcohols can be converted into silyl ethers with trimethylsilyl chloride (TMSCl) or similar silyl groups such as t-butyldimethylsilyl chloride (TBDMSCl).  This is a useful procedure for the protection of alcohols.

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Comment section

4 thoughts on “Protection of alcohols as silyl ethers

  1. When a base is used as a catalyst in this reaction, does it first react with the protecting agent via SN2 mechanism or is it added during step 2 to cause deprotonation of the alcohol.

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