Reduction of esters to aldehydes using DIBAL
Description: Esters can be reduced to aldehydes with diisobutylaluminum hydride (DIBAL), a bulky source of hydride ion. Content available for Reactionguide members only. Not a member? Get access for about 30 cents / day!
please tell me how 3 or 4 molecule of DIBAL are used to reduction of alkyl ester
give me detailed mechanism
what’s the meaning of Me on this diagram?
Me means “methyl”, or CH3
Hey, will lithium tri-tert-butoxyaluminum hydride work here, as well, or just for the acid halides? If not, why the selectivity?
Thanks in advance!
Yep – it will also reduce aldehydes. That’s why it’s important to use only 1 equivalent when reducing acid halides, otherwise you get full reduction to the alcohol.