Master Organic Chemistry Reaction Guide

The Malonic Ester Synthesis

Description: The Malonic Ester Synthesis is a method for making substituted carboxylic acids. It is a combination of three reactions: 1) deprotonation, 2) alkylation, 3) acidic ester hydrolysis, and 4) decarboxylation.

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Comment section

5 thoughts on “The Malonic Ester Synthesis

  1. BONUS. Don’t miss the Br(CH2)4Br example. That is the real bonus on this page. Excellent. Overview great.

  2. In the very first picture of the steps of the reaction, I think Na+ is missing from step one – but this was super helpful!

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