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Master Organic Chemistry Reaction Guide

The Malonic Ester Synthesis

Description: The Malonic Ester Synthesis is a method for making substituted carboxylic acids. It is a combination of three reactions: 1) deprotonation, 2) alkylation, 3) acidic ester hydrolysis, and 4) decarboxylation.

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3 thoughts on “The Malonic Ester Synthesis

  1. In the very first picture of the steps of the reaction, I think Na+ is missing from step one – but this was super helpful!

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