The Malonic Ester Synthesis
Description: The Malonic Ester Synthesis is a method for making substituted carboxylic acids. It is a combination of three reactions: 1) deprotonation, 2) alkylation, 3) acidic ester hydrolysis, and 4) decarboxylation.
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BONUS. Don’t miss the Br(CH2)4Br example. That is the real bonus on this page. Excellent. Overview great.
Thank you Kern
So Helpful!! Thank you a lot!
Glad it was helpful Pu. James
In the very first picture of the steps of the reaction, I think Na+ is missing from step one – but this was super helpful!