Master Organic Chemistry Reaction Guide

The Malonic Ester Synthesis

Description: The Malonic Ester Synthesis is a method for making substituted carboxylic acids. It is a combination of three reactions: 1) deprotonation, 2) alkylation, 3) acidic ester hydrolysis, and 4) decarboxylation.

This page is available to MOC Members only.
Sign up here for about 30 cents/ day!





Comment section

3 thoughts on “The Malonic Ester Synthesis

  1. In the very first picture of the steps of the reaction, I think Na+ is missing from step one – but this was super helpful!

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.