Master Organic Chemistry Reaction Guide

The Robinson Annulation

Description: The Robinson annulation is a method for forming six membered rings. It is a sequential combination of the Michael reaction and the Aldol condensation.

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Real-Life Examples:

Org. Synth. 1961, 41, 38

DOI Link: 10.15227/orgsyn.041.0038

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2 thoughts on “The Robinson Annulation

  1. What if we need to synthesis five membered ring instead of six member. What type of base will preferrably help.

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