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Nucleophiles and Electrophiles

Nucleophiles and Electrophiles, Nucleophilicity and Electrophilicity All through the series on understanding where electrons are, and how they flow, we’ve been talking about how the

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Carbonyl Chemistry: 10 Key Concepts (Part 1)

The weaker the base, the better the leaving group. Electron withdrawing groups make the carbonyl more electrophilic. Electron donors make the carbonyl *less* electrophilic. Carboxylic acid derivatives always protonate on carbonyl first. Steric bulk slows down reactions.

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