Reaction Friday

Introducing the Reaction Guide

Introducing the Reaction Guide

October 17, 2012

My main goal at Master Organic Chemistry has always been to provide students with useful resources that they can’t easily find anywhere else. About six months after I started tutoring organic chemistry, I realiz…

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Reaction Friday: Keto-Enol Tautomerism

Reaction Friday: Keto-Enol Tautomerism

April 27, 2012

Today’s Reaction Friday is all about keto-enol tautomersm, the chemistry equivalent of Jekyll and Hyde. Included: Tautomers are constitutional isomers (not resonance forms) The same factors which stabilize alken…

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Reaction Friday – Fischer Esterification

Reaction Friday – Fischer Esterification

April 14, 2012

The Fischer esterification is one of the most important reactions of carboxylic acids. Treatment of carboxylic acids with an alcohol in the presence of acid catalyst leads to the formation of esters, along with the el…

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Reaction Friday – Reduction of Alkynes to Alkenes with Na/NH3

Reaction Friday – Reduction of Alkynes to Alkenes with Na/NH3

April 6, 2012

My apologies for the interruption. I seem to have wrested control of my blog back from the cats for now, but I’m not sure how long this will last. Clever little bugger. One thing I can say though – the cat…

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Reaction Friday: Conversion of Alcohols to Alkyl Chlorides With SOCl2

Reaction Friday: Conversion of Alcohols to Alkyl Chlorides With SOCl2

March 10, 2012

Treatment of alcohols with thionyl chloride (SOCl2) converts alcohols to alkyl chlorides. When the reaction is performed on secondary alcohols with a stereocenter, the reaction proceeds with inversion of configuration…

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Reaction Friday: Friedel Crafts Acylation

Reaction Friday: Friedel Crafts Acylation

March 2, 2012

Today’s Reaction Friday is about the Friedel Crafts acylation of benzene and other aromatics, an important example of electrophilic aromatic substitution. One thing I forgot to say at the bottom is that there…

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Reaction Friday: Formation of Acetals from Ketones

Reaction Friday: Formation of Acetals from Ketones

February 24, 2012

Today’s video is about the formation of acetals from aldehydes and ketones, an important method for the protection of the carbonyl group. One thing I forgot to mention in the video is that the reaction is an equ…

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Reaction Friday: Addition of Grignard Reagents to Ketones

Reaction Friday: Addition of Grignard Reagents to Ketones

February 18, 2012

Grignard reagents are very useful carbon-based nucleophiles and will readily form carbon-carbon bonds with carbonyl compounds. Here the reaction of Grignard reagents with ketones is described, along with several examp…

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Reaction Friday: Oxymercuration of Alkenes using Hg(OAc)2 and NaBH4

Reaction Friday: Oxymercuration of Alkenes using Hg(OAc)2 and NaBH4

February 11, 2012

Reaction Friday is back!!! Today’s video is on a commonly encountered reaction for making alcohols, the oxymercuration of alkenes using Hg(OAc)2 and water, followed by reduction with NaBH4. Thanks to all of thos…

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Reaction Friday: Free-radical chlorination of alkanes

Reaction Friday: Free-radical chlorination of alkanes

January 13, 2012

One of the new things I wanted to do this year was to start doing videos. Since I was starting to run out of reagents to talk about for Reagent Friday, one thought was to start talking about reactions instead – …

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