Master Organic Chemistry Reaction Guide

Alkylation of enolates

Description: Enolates of carbonyl compounds will react with alkyl halides in SN2 reactions to give alkylation products. 

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Real-Life Example:

Org. Synth. 1936, 16, 60

DOI Link: 10.15227/orgsyn.016.0060

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Org. Synth. 1948, 28, 8

DOI Link: 10.15227/orgsyn.028.0008

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Org. Synth. 1948, 28, 8

DOI Link: 10.15227/orgsyn.021.0099

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Comment section

4 thoughts on “Alkylation of enolates

  1. Why in the fourth reaction was formed the least substituted enolate? More substituted enolate (and pi bond) wouldn’t be more stable?

    Great site!

  2. There’s just a little different: the last quiz shows ID:1781 on the front but ID:1781 on the back.

    Thank you for showing so many examples.
    That’s really helpful.

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