bulky base

Deciding SN1/SN2/E1/E2 (2) – The Nucleophile/Base

Deciding SN1/SN2/E1/E2 (2) – The Nucleophile/Base

November 30, 2012

Last time I talked about the process of deciding if a reaction goes through SN1, SN2, E1, or E2 as asking a series of questions. I call it The Quick N’ Dirty Guide To SN1/SN2/E1/E2. This is the second instalme…

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Bulky Bases in Elimination Reactions

Bulky Bases in Elimination Reactions

October 24, 2012

We’ve recently talked about Zaitsev’s rule in elimination reactions, and how the transition state leading to the more substituted alkene is lower in energy. The bottom line in elimination reactions is that…

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The Most Annoying Exceptions in Org 1 (Part 2)

The Most Annoying Exceptions in Org 1 (Part 2)

February 4, 2011

Last time we talked about how some interesting electronic effects can lead to unexpected results in organic chemistry. Today we look at three examples of how steric factors can  lead to unexpected products (or lack o…

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