imine

The Ruff Degradation and Kiliani-Fischer Synthesis

The Ruff Degradation and Kiliani-Fischer Synthesis

October 29, 2018

The cyanide ion (CN–) can be a very useful tool for extending carbon chains by a single carbon. A familiar example is the reaction of cyanide ion with primary alkyl halides in a nucleophilic substitution reaction (S…

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Reductive Amination

Reductive Amination

September 1, 2017

Reminder: Alkylation of Amines Is Rarely The Answer OK – so making amines through direct alkylation is generally not a great way to go. You could even say it’s crappy. What’s the “right” …

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