Friedel-Crafts acylation of aromatic groups to give ketones
Description: In the presence of a catalyst such as FeCl3 or AlCl3 , acyl chlorides will add to aromatic groups to form aromatic ketones. This is called the Friedel-Crafts acylation reaction.
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{ 4 comments… read them below or add one }
Hi there! I’m doing a problem in my book (don’t worry, it’s not graded hw), and I was wondering, would it be possible to add an anhydride with this reaction? Or would sterics/other reasons prevent that?
Can friedel-Crafts acylation be used to create an aldehyde. In other words, can the R group on the chloride acyl be a H?
Thats Gatterman Koch Reaction. It is based on F.C. Acylation
My textbook uses aluminum as the metal ion and you used iron (III). Does it matter what metal ion you use so long as the halide matches?