Friedel-Crafts acylation of aromatic groups to give ketones

by James

Description: In the presence of a catalyst such as FeCl3 or AlCl3 , acyl chlorides will add to aromatic groups to form aromatic ketones. This is called the Friedel-Crafts acylation reaction.
Content available for Reactionguide members only. Not a member? Get access for about 30 cents / day!

{ 5 comments… read them below or add one }

Kahla Vise

Hi there! I’m doing a problem in my book (don’t worry, it’s not graded hw), and I was wondering, would it be possible to add an anhydride with this reaction? Or would sterics/other reasons prevent that?


Amelia Abbott-Frey

Can friedel-Crafts acylation be used to create an aldehyde. In other words, can the R group on the chloride acyl be a H?


Kartik Anand

Thats Gatterman Koch Reaction. It is based on F.C. Acylation


Alex b

No you may not get benzaldehyde through FC. under the reaction conditions halodehydes will decompose forming hcl.


Caitlin Aschliman

My textbook uses aluminum as the metal ion and you used iron (III). Does it matter what metal ion you use so long as the halide matches?


Leave a Comment