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Master Organic Chemistry Reaction Guide

Friedel-Crafts acylation of aromatic groups to give ketones

Description: In the presence of a catalyst such as FeCl3 or AlCl3 , acyl chlorides will add to aromatic groups to form aromatic ketones. This is called the Friedel-Crafts acylation reaction.

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Real-Life Examples:

Org. Synth. 1933, 13, 12

DOI Link: 10.15227/orgsyn.013.0012

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Org. Synth. 1932, 12, 16

DOI Link: 10.15227/orgsyn.012.0016

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Org. Synth. 1934, 14, 40

DOI Link: 10.15227/orgsyn.014.0040

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Org. Synth. 1935, 15, 77

DOI Link: 10.15227/orgsyn.015.0077

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Org. Synth. 1940, 20, 1

DOI Link: 10.15227/orgsyn.020.0001

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Org. Synth. 1940, 20, 94

DOI Link: 10.15227/orgsyn.020.0094

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Org. Synth. 1950, 30, 1

DOI Link: 10.15227/orgsyn.030.0001

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Comments

Comment section

10 thoughts on “Friedel-Crafts acylation of aromatic groups to give ketones

  1. Hi there! I’m doing a problem in my book (don’t worry, it’s not graded hw), and I was wondering, would it be possible to add an anhydride with this reaction? Or would sterics/other reasons prevent that?

  2. Can friedel-Crafts acylation be used to create an aldehyde. In other words, can the R group on the chloride acyl be a H?

    1. No you may not get benzaldehyde through FC. under the reaction conditions halodehydes will decompose forming hcl.

  3. My textbook uses aluminum as the metal ion and you used iron (III). Does it matter what metal ion you use so long as the halide matches?

  4. Excuse me, there’s some thing really confused me.
    Why benzophenone cannot under go Friedel-Crafts acylation?
    Does it is for the reason that the carbonyl group is deactivating or that benzophenone has highly conjugated system to protect it from acylation or any other reasons?

    Thank you very much.

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