elimination

The Hofmann Elimination

The Hofmann Elimination

October 18, 2017

The Hofmann Elimination is an elimination reaction that forms C-C double (pi) bonds that specifically occurs when the leaving group is NR3 [note] It proceeds through an E2 mechanism. Although the key concepts are no …

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Elimination of Alcohols To Alkenes With POCl3

Elimination of Alcohols To Alkenes With POCl3

April 28, 2015

Here’s what we talk about today: more eliminations of alcohols!  Note that this reagent isn’t covered in all courses, but I’ll include it here for completeness’ sake. We’ve talked about…

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Elimination Reactions of Alcohols

Elimination Reactions of Alcohols

April 16, 2015

Here’s a summary of what we talk about in today’s post. Hydrohalic acids (HX)  plus alcohols give substitution products… We just saw that treating an alcohol with a strong hydrohalic acid – th…

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Synthesis (3) – Reactions of Alkyl Halides

Synthesis (3) – Reactions of Alkyl Halides

January 10, 2014

In the last post, we began our discussion of synthesis by starting with the reactions of alkanes. Since we’ve learned only one important class of alkane reactions so far (free-radical halogenation), our “r…

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Guest Post on SN1/SN2/E1/E2 (4): The Electrophile

Guest Post on SN1/SN2/E1/E2 (4): The Electrophile

November 14, 2013

For the previous posts in Adam’s series on the SN1/SN2/E1/E2, see Part 1 Part 2 Part 3. – James Three And A Half Steps To Any Substitution or Elimination Reaction, Step 2: The Nature of The Electrophile by…

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Guest Post on SN1/SN2/E1/E2 (2): Three And A Half Steps To Any Substitution Or Elimination Reaction

Guest Post on SN1/SN2/E1/E2 (2): Three And A Half Steps To Any Substitution Or Elimination Reaction

November 7, 2013

The second in a series of guest posts on SN1/SN2/E1/E2 by Chemistry Blog author and “instructor of organic chemistry at a small Midwestern liberal arts college” @azmanam  . For the first post, click here.…

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Alkynes Via Elimination Reactions

Alkynes Via Elimination Reactions

June 11, 2013

We’ve gone through elimination reactions before – treatment of alkyl halides with base gives alkenes. Some time ago we discussed elimination reactions here. Elimination reactions follow the general pattern…

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Addition Reactions: Elimination’s Opposite

Addition Reactions: Elimination’s Opposite

January 22, 2013

In previous series, we’ve discussed acid-base reactions, nucleophilic substitution reactions, and elimination reactions. These represent three of the four most important reaction types in a typical Org 1 course.…

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Wrapup: The Quick N’ Dirty Guide To SN1/SN2/E1/E2

Wrapup: The Quick N’ Dirty Guide To SN1/SN2/E1/E2

January 18, 2013

The previous several posts dealt with an approach to solving substitution and elimination problems that can only be described as a Quick N’ Dirty Guide to SN1/SN2/E1/E2. The basic premise is this: given 15-20 mi…

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Deciding SN1/SN2/E1/E2 (4) – The Temperature

Deciding SN1/SN2/E1/E2 (4) – The Temperature

December 19, 2012

The Quick N’ Dirty Guide To Determining SN1/SN2/E1/E2, Part 4 In previous installations of the Quick N’ Dirty Guide, we’ve examined the substrate, the base/nucleophile, and the solvent. Today, weR…

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