nucleophile

How To Make Alcohols More Reactive

How To Make Alcohols More Reactive

October 6, 2014

In the last post we explored some of the properties and nomenclature of alcohols. We said that alcohols tend to have high boiling points due to hydrogen bonding, and that  we commonly divide alcohols into the cate…

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Guest Post On SN1/SN2/E1/E2 (6): Wrapup

Guest Post On SN1/SN2/E1/E2 (6): Wrapup

November 21, 2013

Part 6 of a 6 part series. Previous posts in the series:  1 2 3 4 5 – James  3 ½ Steps To Any SN1/SN2/E1/E2 Reaction: Wrap Up And Cautions, by @azmanam Congratulations! You now have all the information you …

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Wrapup: The Quick N’ Dirty Guide To SN1/SN2/E1/E2

Wrapup: The Quick N’ Dirty Guide To SN1/SN2/E1/E2

January 18, 2013

The previous several posts dealt with an approach to solving substitution and elimination problems that can only be described as a Quick N’ Dirty Guide to SN1/SN2/E1/E2. The basic premise is this: given 15-20 mi…

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Deciding SN1/SN2/E1/E2 (2) – The Nucleophile/Base

Deciding SN1/SN2/E1/E2 (2) – The Nucleophile/Base

November 30, 2012

Last time I talked about the process of deciding if a reaction goes through SN1, SN2, E1, or E2 as asking a series of questions. I call it The Quick N’ Dirty Guide To SN1/SN2/E1/E2. This is the second instalme…

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Comparing the E1 and SN1 Reactions

Comparing the E1 and SN1 Reactions

November 8, 2012

Imagine you’re starting with the alcohol on the left and you’d like to get to the alkene on the right. What bonds are formed and broken here? We’re forming C-C (π), we’re breaking C-H, and we&…

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Elimination Reactions Are Favored By Heat

Elimination Reactions Are Favored By Heat

September 10, 2012

A few posts back we saw how elimination reactions are often in competition with substitution reactions. ow do we know when one reaction pathway is going to be preferred over another? As we’ll see, there are goin…

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Two Types of Substitution Reactions

Two Types of Substitution Reactions

June 27, 2012

Chemistry is an experimental science. There is no great Ramanujan of our discipline, who, starting with a simple set of premises, could derive and predict all of the depth and variety of modern chemistry. No, it is mu…

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Walkthrough of Substitution Reactions (1) – Introduction

Walkthrough of Substitution Reactions (1) – Introduction

May 31, 2012

Today starts a new series of posts on walking through one of the key classes of reaction in organic chemistry: substitution reactions. The goal of this series is to teach you:  How to recognize substitution reactions…

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Acid Base Reactions Are Fast

Acid Base Reactions Are Fast

May 21, 2012

Common dilemma in organic chemistry as you move through the latter parts of Org 1 and then into Org 2: When more than one reaction is possible, how do you know which one will happen? In a steel cage match between an a…

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