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Another Exercise In Mind Reading

Another Exercise In Mind Reading

April 17, 2013

Here’s another great example of how one reagent used in a certain context performs one thing, and in a different context performs a completely different task. These are the types of inconsistencies which lead st…

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Acid Base Reactions: What’s the Point?

Acid Base Reactions: What’s the Point?

May 30, 2012

One thing has been missing from our discussion of acid-base reactions. Who cares? What does it matter that we understand acid base reactions? Why is it important? Today, I hope to show that it matters a lot, not only …

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Reagent Friday: Zinc Amalgam (Zn-Hg)

Reagent Friday: Zinc Amalgam (Zn-Hg)

December 9, 2011

In a blatant plug for the Reagent Guide and the Reagents App for iPhone, each Friday  I profile a different reagent that is commonly encountered in Org 1/ Org 2.  What it’s used for: For our purposes, zinc…

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Introduction to Elimination Reactions

Introduction to Elimination Reactions

October 10, 2011

As  part 4 of the most important reactions you learn in org 1, (acid-base, substitution, and addition) here’s an introduction to the elimination reaction. This series requires that you understand how to read li…

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Reagent Friday: Lithium Di-isopropyl Amide (LDA)

Reagent Friday: Lithium Di-isopropyl Amide (LDA)

August 5, 2011

In a blatant plug for the Reagent Guide, each Friday  I profile a different reagent that is commonly encountered in Org 1/ Org 2. Version 1.2 just got released last week, with a host of corrections and a new page in…

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Reagent Friday: Sodium Amide (NaNH2)

Reagent Friday: Sodium Amide (NaNH2)

July 29, 2011

In a blatant plug for the Reagent Guide, each Friday  I profile a different reagent that is commonly encountered in Org 1/ Org 2. Version 1.2 just got released this week, with a host of corrections and a new page in…

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Carbonyl chemistry: Anionic versus Neutral Nucleophiles

Carbonyl chemistry: Anionic versus Neutral Nucleophiles

March 24, 2011

Let’s talk about carbonyl chemistry today (aldehydes, ketones, carboxylic acids, and esters). Specifically, reaction mechanisms. If you look at the reaction mechanisms in detail you will see that they break down…

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From Gen Chem to Organic Chem, Pt. 13 – Equilibria

From Gen Chem to Organic Chem, Pt. 13 – Equilibria

September 13, 2010

(The last lesson in the series. I wish I had this series done by the time school started for most people, but I initially thought I could cover the basics of Gen Chem in 6 posts and it just kept growing – planni…

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The Acid-Catalyzed Aldol Reaction

The Acid-Catalyzed Aldol Reaction

June 2, 2010

(Part VII of VII on the reactions of neutral nucleophiles in carbonyl chemistry) As I said at the beginning of this series, the thing with reactions of neutral nucleophiles is that their mechanisms tend to involve a l…

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On Acetals and Hemiacetals

On Acetals and Hemiacetals

May 28, 2010

(Part VI on a series of posts on the reactions of neutral nucleophiles with carbonyl compounds) When I started this series on reaction mechanisms of carbonyl compounds, it was in an effort to justify a little statemen…

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