Nucleophilic Addition To Carbonyls
Nucleophilic Addition To Carbonyls The most important reaction of the carbonyl group (C=O) is the addition of nucleophiles to the carbonyl carbon, sometimes called, “1,2-addition”.
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Formation of Grignard and Organolithium Reagents
Formation or Grignard Reagents and Organolithium Reagents From Alkyl and Alkenyl Halides In the last post we introduced the concept of organometallic compounds – molecules
Read moreSynthesis Problems Involving Grignard Reagents
Grignard Practice Problems: Synthesis Exercises Involving Grignard Reagents Grignard reagents add once to aldehydes to give secondary alcohols and also add once to ketones to give tertiary
Read moreGrignard Reactions And Synthesis (2)
More Grignard Practice Problems, This Time Incorporating Oxidation Here’s the summary for today’s post on synthesis incorporating Grignard reagents and oxidants. Converting an aldehyde into
Read moreAnother Exercise In Mind Reading
Here’s another great example of how one reagent used in a certain context performs one thing, and in a different context performs a completely different
Read moreOrganic Chemistry Study Tips: Reaction Maps
This time of year one of the most common problems students come to me with is how to do synthesis problems. Like this: There’s a
Read moreWhy organic chemistry is hard (2)
Today’s post is about how a simple reaction can lead to all kinds of complications. I’m talking about the Grignard reaction here, although the principles
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